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IVF breakthrough: Docs identify abnormal gene in women suffering repeated treatment failures

WT24 Desk

A GENETIC “fingerprint” may soon help doctors predict the chances of successful IVF treatment, The Sun reports.   Researchers claim to have pinpointed an abnormal gene in women who had suffered repeated failures.

It is hoped the breakthrough could save families the heartache of costly failed treatment.  Prof Nick Macklon, of Complete Fertility Centre Southampton, who is leading the study, said: “This is very significant.  “Many women undergo a number of IVF cycles without success despite having good-quality embryos.

“Up to now it has been unclear whether or not the lining of the womb may be the cause. But a specific gene ‘fingerprint’, when present, is always associated with failure.”  Women were recruited for the study in Holland between 2006 and 2007, then 2011 and 2013.

Researchers tested womb linings of 43 with recurrent IVF implantation failure and 72 who gave birth after IVF or an alternative treatment. They found an abnormal gene profile in 80 per cent of women with repeated failures which was not present in those who gave birth.

Further trials will take place. Prof Frank Holstege, of University Medical Centre Utrecht, said: “This gives clinicians much more clarity in counselling patients as to the wisdom of investing further time, effort and money in ongoing

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